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			</style>[an error occurred while processing this directive]<div class="content-width"><ol class="breadcrumb text-uppercase"><li><a href="/">Home</a></li><li><a href="/aboutus/">About Us</a></li><li><a href="/people/">People</a></li><li><a href="/people/Xin.Zhou"><span itemprop="name">Xin Zhou</span></a></li><li class="active">Publications</li></ol></div><!-- MOBILE NAVIGATION --><div class="content-width space-below mobile-menu-placeholder visible-xs visible-sm"></div><!-- COLUMNS --><div class="container-fluid content-width"><div class="row"><div class="col-xs-12 col-md-9 col-md-push-3" id="maincontent"><!-- CONTENT (Column 2) --><div class="page-title"><h1>Xin Zhou : Publications
</h1></div><div role="toolbar" class="btn-toolbar"><div class="btn-group"><a href="/people/publications/personal/Xin.Zhou.html" aria-hidden="true" type="button" class="btn btn-oxford-blue"><span class="glyphicon glyphicon-sort-by-attributes"></span> Personal ordering</a><a href="/people/publications/bibtex/Xin.Zhou.html" aria-hidden="true" type="button" class="btn btn-default"><span class="glyphicon glyphicon-file"></span> BibTex</a></div></div><p></p><ul class="list-unbulleted list-unbulleted-spaced"><li>
	
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	<p class="publicationTitle"> <strong>
            The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles </strong> </p>
	    <p class="publicationAuthors"> <em> P.K. Vinod&#x201a; Xin Zhou&#x201a; Tongli Zhang&#x201a; Thomas U. Mayer and Bela Novak  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Biophysical Chemistry</em>.
        
            Vol. 177&#x2013;178.
        
            No. 0.
        
                Pages 1 &#x2212; 6.
            2013.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication7319-abstract.html">
			Details <span class="sr-only" > about <em> The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles  </em></span> </a> |
			<a href="/publications/publication7319.bib">
			BibTeX  <span class="sr-only" > data for <em> The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.bpc.2013.03.002">
		DOI (10.1016/j.bpc.2013.03.002)
		</a> 
					| <a href="http://www.sciencedirect.com/science/article/pii/S0301462213000574"> Link <span class="sr-only" > to <em> The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; A. Bueno&#x2212;Orovio&#x201a; M. Orini&#x201a; B. Hanson&#x201a; M. Hayward&#x201a; P. Taggart&#x201a; P.D. Lambiase&#x201a; K. Burrage and B. Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
            In  
            <em>
            Computing in Cardiology Conference (CinC)&#x201a; 2013</em>.
        
                Pages 855&#x2212;858.
            September,
            2013.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication8534-abstract.html">
			Details <span class="sr-only" > about <em> Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans  </em></span> </a> |
			<a href="/publications/publication8534.bib">
			BibTeX  <span class="sr-only" > data for <em> Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans  </em></span>   </a>
			
			
		
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	<p class="publicationTitle"> <strong>
            HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; A. Bueno&#x2212;Orovio&#x201a; M. Orini&#x201a; B. Hanson&#x201a; M. Hayward&#x201a; P. Taggart&#x201a; P.D. Lambiase&#x201a; K. Burrage and B. Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
            In  
            <em>
            Heart Rhythm</em>.
        
            Vol. 11.
        
            No. 5 Supplement.
        May,
            2014.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9032-abstract.html">
			Details <span class="sr-only" > about <em> HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance  </em></span> </a> |
			<a href="/publications/publication9032.bib">
			BibTeX  <span class="sr-only" > data for <em> HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance  </em></span>   </a>
			
			
					| <a href="http://www.heartrhythmjournal.com/article/S1547-5271(14)00309-9/abstract"> Link <span class="sr-only" > to <em> HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart. </strong> </p>
	    <p class="publicationAuthors"> <em> Diogo Santos&#x201a; Michele Orini&#x201a; Xin Zhou&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Ben Hanson&#x201a; Peter Taggart&#x201a; Martin Hayward&#x201a; Blanca Rodriguez and Pier Lambiase  </em> </p>
	
	<p class="publicationDetails"> 
                Pages 157&#x2212;160.
            2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13810-abstract.html">
			Details <span class="sr-only" > about <em> Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.  </em></span> </a> |
			<a href="/publications/publication13810.bib">
			BibTeX  <span class="sr-only" > data for <em> Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.  </em></span>   </a>
			
			
		
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	<p class="publicationTitle"> <strong>
            How can a gain&#x2212;of&#x2212;function mutation in KCNQ1 lead to action potential prolongation? </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; Stephen Harmer&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Kevin Burrage&#x201a; Andrew Tinker and Blanca Rodriguez.  </em> </p>
	
	<p class="publicationDetails"> 
                Pages 13(5) S545.
            2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13811-abstract.html">
			Details <span class="sr-only" > about <em> How can a gain&#x2212;of&#x2212;function mutation in KCNQ1 lead to action potential prolongation?  </em></span> </a> |
			<a href="/publications/publication13811.bib">
			BibTeX  <span class="sr-only" > data for <em> How can a gain&#x2212;of&#x2212;function mutation in KCNQ1 lead to action potential prolongation?  </em></span>   </a>
			
			
		
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	<p class="publicationTitle"> <strong>
            Human&#x2212;based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop </strong> </p>
	    <p class="publicationAuthors"> <em> Blanca Rodriguez&#x201a; Annamaria Carusi&#x201a; Najah Abi&#x2212;Gerges&#x201a; Rina Ariga&#x201a; Oliver Britton&#x201a; Gil Bub&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Rebecca A. B. Burton&#x201a; Valentina Carapella&#x201a; Louie Cardone&#x2212;Noott&#x201a; Matthew J. Daniels&#x201a; Mark R. Davies&#x201a; Sara Dutta&#x201a; Andre Ghetti&#x201a; Vicente Grau&#x201a; Stephen Harmer&#x201a; Ivan Kopljar&#x201a; Pier Lambiase&#x201a; Hua Rong Lu&#x201a; Aurore Lyon&#x201a; Ana Minchole&#x201a; Anna Muszkiewicz&#x201a; Julien Oster&#x201a; Michelangelo Paci&#x201a; Elisa Passini&#x201a; Stefano Severi&#x201a; Peter Taggart&#x201a; Andy Tinker&#x201a; Jean&#x2212;Pierre Valentin&#x201a; Andras Varro&#x201a; Mikael Wallman and Xin Zhou  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Europace</em>.
        2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication10262-abstract.html">
			Details <span class="sr-only" > about <em> Human&#x2212;based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop  </em></span> </a> |
			<a href="/publications/publication10262.bib">
			BibTeX  <span class="sr-only" > data for <em> Human&#x2212;based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1093/europace/euv320">
		DOI (10.1093/europace/euv320)
		</a> 
					| <a href="http://europace.oxfordjournals.org/content/early/2015/11/29/europace.euv320.long"> Link <span class="sr-only" > to <em> Human&#x2212;based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Variability in cardiac electrophysiology: Using experimentally&#x2212;calibrated populations of models to move beyond the single virtual physiological human paradigm. </strong> </p>
	    <p class="publicationAuthors"> <em> Anna Muszkiewicz&#x201a; Oliver J. Britton&#x201a; Philip Gemmell&#x201a; Elisa Passini&#x201a; Carlos S&#xe1;nchez&#x201a; Xin Zhou&#x201a; Annamaria Carusi&#x201a; T. Alexander Quinn&#x201a; Kevin Burrage&#x201a; Alfonso Bueno&#x2212;Orovio and Blanca Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Progress in Biophysics and Molecular Biology</em>.
        2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication10263-abstract.html">
			Details <span class="sr-only" > about <em> Variability in cardiac electrophysiology: Using experimentally&#x2212;calibrated populations of models to move beyond the single virtual physiological human paradigm.  </em></span> </a> |
			<a href="/publications/publication10263.bib">
			BibTeX  <span class="sr-only" > data for <em> Variability in cardiac electrophysiology: Using experimentally&#x2212;calibrated populations of models to move beyond the single virtual physiological human paradigm.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.002">
		DOI (10.1016/j.pbiomolbio.2015.12.002)
		</a> 
					| <a href="http://www.ncbi.nlm.nih.gov/pubmed/26701222"> Link <span class="sr-only" > to <em> Variability in cardiac electrophysiology: Using experimentally&#x2212;calibrated populations of models to move beyond the single virtual physiological human paradigm.  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Michele Orini&#x201a; Ben Hanson&#x201a; Martin Hayward&#x201a; Peter Taggart&#x201a; Pier D. Lambiase&#x201a; Kevin Burrage and Blanca Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Circulation Research</em>.
        2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication10264-abstract.html">
			Details <span class="sr-only" > about <em> In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes  </em></span> </a> |
			<a href="/publications/publication10264.bib">
			BibTeX  <span class="sr-only" > data for <em> In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1161/CIRCRESAHA.115.307836">
		DOI (10.1161/CIRCRESAHA.115.307836)
		</a> 
					| <a href="http://circres.ahajournals.org/content/early/2015/11/24/CIRCRESAHA.115.307836.abstract"> Link <span class="sr-only" > to <em> In Vivo and In Silico Investigation into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            In silico evaluation of arrhythmia. </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; Alfonso Bueno&#x2212;Orovio and Blanca Rodriguez.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Current Opinion in Physiology</em>.
        
                Pages 01:95&#x2013;103.
            2018.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13812-abstract.html">
			Details <span class="sr-only" > about <em> In silico evaluation of arrhythmia.  </em></span> </a> |
			<a href="/publications/publication13812.bib">
			BibTeX  <span class="sr-only" > data for <em> In silico evaluation of arrhythmia.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.cophys.2017.11.003">
		DOI (10.1016/j.cophys.2017.11.003)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study. </strong> </p>
	    <p class="publicationAuthors"> <em> Jakub Tomek&#x201a; Mark&#xe9;ta Tomkov&#xe1;&#x201a; Xin Zhou&#x201a; Gil Bub and Blanca Rodriguez.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Frontiers in Physiology</em>.
        
                Pages 9:1306.
            September,
            2018.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13813-abstract.html">
			Details <span class="sr-only" > about <em> Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study.  </em></span> </a> |
			<a href="/publications/publication13813.bib">
			BibTeX  <span class="sr-only" > data for <em> Modulation of cardiac alternans by altered sarcoplasmic reticulum calcium release: a simulation study.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.3389/fphys.2018.01306">
		DOI (10.3389/fphys.2018.01306)
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	<p class="publicationTitle"> <strong>
            Investigating the complex arrhythmic phenotype caused by a potassium channel gain&#x2212;of&#x2212;function mutation. </strong> </p>
	    <p class="publicationAuthors"> <em> Blanca Rodriguez Xin Zhou Alfonso Bueno&#x2212;Orovio Richard J. Schilling Claire Kirkby Chris Denning Divya Rajamohan Kevin Burrage Andrew Tinker and Stephen C. Harmer.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Frontiers in Physiology</em>.
        
                Pages 10: 259.
            March,
            2019.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13814-abstract.html">
			Details <span class="sr-only" > about <em> Investigating the complex arrhythmic phenotype caused by a potassium channel gain&#x2212;of&#x2212;function mutation.  </em></span> </a> |
			<a href="/publications/publication13814.bib">
			BibTeX  <span class="sr-only" > data for <em> Investigating the complex arrhythmic phenotype caused by a potassium channel gain&#x2212;of&#x2212;function mutation.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.3389/fphys.2019.00259">
		DOI (10.3389/fphys.2019.00259)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo&#x2212;ECG. </strong> </p>
	    <p class="publicationAuthors"> <em> Vanessa D&#xed;az&#x2212;Zuccarini. Carlos A. Ledezma Xin Zhou Blanca Rodr&#xed;guez P. J. Tan  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Plos One</em>.
        
                Pages 12;14(8): e0220294.
            August,
            2019.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13815-abstract.html">
			Details <span class="sr-only" > about <em> A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo&#x2212;ECG.  </em></span> </a> |
			<a href="/publications/publication13815.bib">
			BibTeX  <span class="sr-only" > data for <em> A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo&#x2212;ECG.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1371/journal.pone.0220294">
		DOI (10.1371/journal.pone.0220294)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            Development&#x201a; calibration&#x201a; and validation of a novel human ventricular myocyte model in health&#x201a; disease and drug block. </strong> </p>
	    <p class="publicationAuthors"> <em> Jakub Tomek&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Elisa Passini&#x201a; Xin Zhou&#x201a; Ana Minchole&#x201a; Oliver Britton&#x201a; Chiara Bartolucci&#x201a; Stefano Severi&#x201a; Alvin Shrier&#x201a; Laszlo Virag&#x201a; Andras Varro and Blanca Rodriguez.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>eLife</em>.
        
                Pages 8. pii: e48890.
            December,
            2019.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13817-abstract.html">
			Details <span class="sr-only" > about <em> Development&#x201a; calibration&#x201a; and validation of a novel human ventricular myocyte model in health&#x201a; disease and drug block.  </em></span> </a> |
			<a href="/publications/publication13817.bib">
			BibTeX  <span class="sr-only" > data for <em> Development&#x201a; calibration&#x201a; and validation of a novel human ventricular myocyte model in health&#x201a; disease and drug block.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.7554/eLife.48890">
		DOI (10.7554/eLife.48890)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico. </strong> </p>
	    <p class="publicationAuthors"> <em> David G. Strauss. Zhihua Li Gary R. Mirams Takashi Yoshinaga Bradley J Ridder Xiaomei Han Janell E. Chen Norman L. Stockbridge Todd A. Wisialowski Bruce Damiano Stefano Severi Pierre Morissette Peter R. Kowey Mark Holbrook Godfrey Smith Randall L. Rasmusson Michael Liu Zhen Song Zhilin Qu Derek J. Leishman Jill Steidl&#x2212;Nichols Blanca Rodriguez Alfonso Bueno&#x2212;Orovio Xin Zhou Elisa Passini Andrew G. Edwards Stefano Morotti Haibo Ni Eleonora Grandi Colleen E. Clancy Jamie Vandenberg Adam Hill Mikiko Nakamura Thomas Singer Liudmila Polonchuk Andrea Greiter&#x2212;Wilke Ken Wang Stephane Nave Aaron Fullerton Eric A. Sobie Michelangelo Paci Flora Musuamba Tshinanu  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Clinical Pharmacology and Therapeutics</em>.
        
                Pages 107(1):102&#x2212;111.
            January,
            2020.
        </p>
	
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            		href="/publications/publication13816-abstract.html">
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			 | <a
		href="http://dx.doi.org/10.1002/cpt.1647">
		DOI (10.1002/cpt.1647)
		</a> 
		
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		>
			
	
	<p class="publicationTitle"> <strong>
            Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment. </strong> </p>
	    <p class="publicationAuthors"> <em> Xin Zhou&#x201a; Yusheng Qu&#x201a; Elisa Passini&#x201a; Alfonso Bueno&#x2212;Orovio&#x201a; Yang Liu&#x201a; Hugo Vargas and Blanca Rodriguez.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Frontiers in Pharmacology</em>.
        
                Pages 10:1643.
            January,
            2020.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication13818-abstract.html">
			Details <span class="sr-only" > about <em> Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.  </em></span> </a> |
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			BibTeX  <span class="sr-only" > data for <em> Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment.  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.3389/fphar.2019.01643">
		DOI (10.3389/fphar.2019.01643)
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	<p class="publicationTitle"> <strong>
            The virtual assay software for human in silico drug trials to augment drug cardiac testing. </strong> </p>
	    <p class="publicationAuthors"> <em> Blanca Rodriguez Elisa Passini Xin Zhou Cristian Trovato Oliver J Britton Alfonso Bueno&#x2212;Orovio  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Computational Science</em>.
        2020.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication14412-abstract.html">
			Details <span class="sr-only" > about <em> The virtual assay software for human in silico drug trials to augment drug cardiac testing.  </em></span> </a> |
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	<p class="publicationTitle"> <strong>
            Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability. </strong> </p>
	    <p class="publicationAuthors"> <em> Hector Martinez&#x2212;Navarro&#x201a; Xin Zhou&#x201a; Alfonso Bueno&#x2212;Orovio and Blanca Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>The Royal Society Interface Focus</em>.
        2020.
        </p>
	
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            		href="/publications/publication14413-abstract.html">
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